Skin injuries: Pro-inflammatory vs. minimal inflammatory healing

Micro-needling creates hundreds of micro-injuries in the dermis, triggering the body’s natural wound healing process. The first phase in this healing process is the inflammatory phase, during which tissues immediately react to the injury, assess the damage and call the body’s repair systems to action. During inflammation, platelet aggregation is followed by infiltration of leukocytes (white blood cells) into the wound site.


Pro-inflammatory vs. minimal inflammatory healing

This inflammatory phase shapes how the body is going to react for the remainder of the wound healing response. Whether there is an excessive or a minimal influx of infiltrating leukocytes into the damaged tissue may have profound effects on downstream cell migration, proliferation, differentiation and, ultimately, the quality of the healing response. The amount of inflammation plays a major role in determining whether the body develops scar tissue during the healing process

There are several options the body can take in response to injuries, each with a varying degree of inflammatory involvement. Cytokines play a role in determining which pathway is activated. Cytokines are cell-signaling molecules that aid cell-to-cell communication in immune responses and stimulate the movement of cells toward sites of inflammation, infection and trauma.

Pro-inflammatory healing

Pro-inflammatory cytokines incite and amplify inflammatory reactions. Pro-inflammatory cytokines trigger a panic mode (“send help now!”), leading to fast initial response to injury. It has been observed that when there is a robust inflammatory response (large number of infiltrate cells and higher pro-inflammatory cytokines) there is a higher likelihood that scar tissue will be formed at the injury site.

Minimal inflammatory healing

Anti-inflammatory cytokines are involved in the reduction of infiltrate cells and pro-inflammatory cytokines during inflammatory reactions. The release of a higher proportion of anti-inflammatory cytokines to pro-inflammatory cytokines is the “non-panic mode” that reduces the chances of scar tissue formation.

Micro-needling as a solution

Micro-needling using SkinPen triggers the minimal inflammatory healing response. It is thought that through this, micro-needling doesn’t lead to scar tissue formation when performed correctly. Instead, SkinPen assists in the remodeling of extracellular matrix, including collagen and elastin.

Skinfuse post-procedure skincare products provide essential skin cell nutrients that optimize healthy skin following the SkinPen micro-needling procedure. Skinfuse RESCUE Calming Complex provides ingredients known to reduce inflammation, and none of Skinfuse post-procedure products contain ingredients that are known to cause irritation of inflammation. Skinfuse in the right choice for your skin following a SkinPen procedure. SkinFuse and SkinPen complement each other, improving the chances for the best results from your SkinPen procedure.

Contact your SkinPen provider to learn how SkinPen and Skinfuse can help reverse the signs of aging, revive skin health and reveal beautiful skin.