The relationship between “growth factor” products and SkinPen

Micro-needling is a skin rejuvenation procedure that stimulates the body’s own natural wound healing process. Wound healing is regulated by a complex signaling network consisting of growth factors and cytokines. Micro-needling releases cytokines, including growth factors, during the procedure.

Cytokines are signaling proteins that stimulate cell growth, differentiation, survival, inflammation and tissue repair. The types and amounts of cytokines released during micro-needling are limited to those found in platelets, blood serum and lymph. However, those cytokines signal cells in the damaged tissue to release other cytokines that in turn release others in a process known as the wound healing cascade.


Micro-needling Protocols

Some micro-needling protocols include the application of topical “growth factors” products. While external application of appropriate, viable growth factors, in conjunction with micro-needling, may assist with skin rejuvenation, there is limited scientific evidence to suggest that using externally derived growth factors is necessary or beneficial to the micro-needling process. There is no evidence to suggest that using topical growth factors would hinder the micro-needling process, however here are several considerations if you choose to use topical “growth factor” products in addition to the SkinPen micro-needling procedure:

Timing of growth factor delivery.

Growth factors are large proteins that aren’t likely to penetrate intact skin. Therefore, growth factors should be used when the micro-channels are open (up to 20-plus hours after the micro-needling procedure). One study found that micro-needling allowed growth factors to penetrate into the dermal tissues instead of sitting on top of the skin’s surface.

Products must be intended for use on “broken” skin.

Products containing growth factors must be formulated for use on open or broken skin, as foreign contaminants and certain ingredients found in some products may increase the risk of adverse events such as irritation, inflammation, necrosis and infection.

Choose products with no or minimal irritating ingredients.

Some ingredients may interfere with the tissue remodeling process. Avoid ingredients such as fragrances or dyes that cause inflammation or don’t allow the skin to reach homeostasis. If ingredients stimulate the pro-inflammatory pathway, the product may reduce the beneficial effects of the SkinPen micro-needling procedure.

Know what’s in your skincare products.

Look for products that contain stable, viable growth factors (meaning there is data to show that the proteins are quality tested per batch). Growth factors are typically not stable for long periods of time and will likely degrade in the bottle or on your skin unless there are technologies in place that preserve them. Therefore, you should always inquire as to which growth factors are in the product, in what amounts, whether they are stable/active and what data is available to support these claims.

The Skinfuse post-procedure skincare products do not contain growth factors, as there is little evidence to show that there is a benefit for use of these technologies in conjunction with micro-needling. The Skinfuse products were specifically formulated to provide the nutrients your skin needs to enhance the results of the SkinPen micro-needling procedure. Skinfuse is the best choice for your skin following a SkinPen procedure.

Contact your SkinPen provider to learn how SkinPen and Skinfuse can help improve the health and appearance of your skin.